3-Methoxytyramine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

3-Methoxytyramine salticide 是多巴胺的无活性代谢物，可以激活微量胺相关受体 1 (TAAR1)。

3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1). 3-methoxytyramine can be found primarily in human brain and most tissues tissues; and in blood cerebrospinal fluid (csf) or urine. Within a cell 3-methoxytyramine is primarily located in the cytoplasm.

The intensity of the fluorescence developed is in a linear relation to the amount of 3-Methoxytyramine hydrochloride presented in the sample up to at least 1 μg. When a high concentration of dopamine is present in the reaction mixture, there is some reduction in the fluorescence derived from3-Methoxytyramine hydrochloride.

The extracellular DA metabolite 3-Methoxytyramine hydrochloride (3-MT) induces significant behavioral activation in DDD mice. This activity however, is mostly presented as a set of disorganized abnormal movements that includes tremor, head bobbing, straub tail, grooming and abnormal orofacial movements rather than normal forward activity. No effect is observed when 3-Methoxytyramine hydrochloride is infused at doses below 9 μg, at 9 μg and higher doses 3-Methoxytyramine hydrochloride dose-dependently causes transient behavioral activation with a complex set of behaviors. In particular, transient hyperactivity and stereotypy, sniffing, grooming, rearing and mild abnormal involuntary movements (AIMs) at the level of limbs is observed after infusion of 9 μg of 3-Methoxytyramine hydrochloride. Similar behaviors are also observed after 18 μg of 3-Methoxytyramine hydrochloride with the additional appearance of tremor as well as oral and whole body AIMs.

3-O-methyl Dopamine hydrochloride | 3-O-methyl Dopamine hydrochloride)

Others

Other Targets

TAAR1

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1477-68-5

203.67

C9H14ClNO2

>98% (HPLC)

DMSO: 100 mg/mL;Water: 50 mg/mL

Cl.COc1cc(CCN)ccc1O

——

(-20℃)

With Ice Pack

≥ 2 years